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The feedback inhibition appears tobe overpowered during stress—rise in ACTH secretioncontinues despite high plasma level of cortisol induced by it.Arginine vasopressin (AVP) enhances the action of CRH oncorticotropes and augments ACTH release. Adaptive T cells can be created without activation by TCR/CD28 engagementor the need for cell division (Walker et al. Rifampin induces NVPmetabolism and makes it ineffective, but has littleeffect on EFV levels.
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Surprisingly, other groups have had varied resultswith Mdm2 overexpression in cell culture when employing mdm-2 cDNA expres-sion vectors.
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